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pentobarbital will lessen the level or effect of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.iloperidone will increase amounts of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Iloperidone is a time-dependent CYP3A inhibitor and will cause elevated plasma levels of me